Hormone-based pharmaceutical intermediate filtration, washing and drying integrated machine

 As an intermediate for the synthesis of steroid hormones, steroid contraceptives and other pharmaceutical products, taro saponin can also be processed into over 180 kinds of drugs, including various drug hormones, analgesics, anesthetics and contraceptives. The traditional processing procedure is: hydrolysis of hormone-based pharmaceutical intermediates → solvent extraction → crystallization → centrifugation and drying → heating and drying → finished product storage. Except for the solvent extraction process which is carried out in a closed container, the centrifugal spin-drying and drying are both conducted in an open system. The machines used are a three-legged centrifugal spin dryer and a drying room (fully open). This process has significant hidden dangers. The solvent evaporation cannot be recovered, resulting in large waste. Workers come into direct contact with the solvent, which causes great harm to their health.

Design Requirements for a fully enclosed crystallization, filtration, washing and drying integrated machine for Hormone-based Pharmaceutical intermediates

To address the deficiencies in the production of traditional hormone-based pharmaceutical intermediates, many pharmaceutical factories have adopted the new technology of fully enclosed solvent extraction. There is an urgent need for solvent-based crystallization, filtration, washing and drying integrated machines that meet the production process requirements, so as to greatly improve the working environment, enhance the efficiency of solvent oil utilization and optimize the process flow.

To achieve the above goals, Wuxi Srui has designed and developed a four-in-one multi-functional equipment for crystallization, filtration, washing and drying, which is mainly manifested in A solvent-based vacuum drying device, including a cylinder, the lower part of which is a conical discharge hopper, is characterized in that a spiral agitator and a filter screen are installed along the axial direction in the cylinder, the agitator is placed in the filter screen, the filter screen is of a cylindrical structure with open ends, the main spiral agitator shaft and a gap between it and the inner wall of the cylinder, and a feeding port is provided on the upper part of the filter screen on the cylinder. A liquid outlet is provided on the cylinder body at the lower part of the filter screen, and the liquid outlet is located at the bottom of the conical discharge hopper.

The side wall of the cylinder of the new type of fully sealed crystallization filtration, washing and drying integrated machine is equipped with a jacket that can pass steam or cooling water. The spiral agitator is composed of a rotating shaft and spiral blades fixed on the rotating shaft. The spiral shaft is driven by a power mechanism located at the top of the cylinder, and a scraper is installed near the inner wall of the filter screen at the outer edge of the spiral blades. A vacuum bag filter connected to the vacuum pumping device is also set on the cylinder body.

The working principle of the fully sealed crystallization, filtration, washing and drying integrated machine for hormone-based pharmaceutical intermediates

The crystalline liquid of the extracted hormone-based pharmaceutical intermediates enters the filter screen inside the cylinder through the feed port at the top of the cylinder. The solvent is filtered out through the filter screen. Assuming that the liquid outlet at the bottom of the cylinder enters the solvent oil storage tank for storage, the crystalline substances are pressed by the screw agitator, and the solvent remaining in the crystalline substances is pressed out for recycling and reuse. The crystalline substances are pressed out from the discharge port at the bottom of the conical discharge.

The fully sealed crystallization, filtration, washing and drying integrated machine has a simple structure and is easy to use. The jacket set on the cylinder can be heated by steam or cooled by circulating water. The spiral agitator set inside the cylinder can rotate in both forward and reverse directions, exerting a stirring and pressing effect on the crystalline substances. When this machine is in operation, the vacuum pumping device can be activated. Through the vacuum pumping machine, the cylinder operates under negative pressure, and the solvent squeezed out from the crystalline substances is extracted by vacuum pumping for recycling and reuse. The crystals are then dried under vacuum.

Structure and operation instructions of the fully enclosed crystallization, filtration, washing and drying integrated machine for hormone-based pharmaceutical intermediates

The four-in-one crystallization, filtration, washing and drying system comprises a cylinder, the lower part of which is a conical discharge hopper. The feature of this cylinder is that a spiral stirring device and a filter screen are installed along the axial direction inside the cylinder. The spiral stirring device is placed in the filter screen, and the filter screen is in a cylindrical structure with open ends. It is coaxial with the spiral stirring device and has a gap with the inner wall of the cylinder. A feeding port is provided on the upper part of the cylinder of the filter screen, and a liquid outlet is provided on the lower part of the cylinder of the filter screen. The discharge port is located at the bottom of the conical discharge hopper.

The four-in-one multi-functional crystallization filter is equipped with a jacket on the side wall of the cylinder that can pass steam into liquid.

③ The cylindrical conical crystallization filtration washing and drying machine is a spiral stirring device composed of a rotating shaft and spiral blades fixed on the rotating shaft. The rotating shaft is driven by a power mechanism located at the top of the cylinder.

The integrated crystallization, filtration and drying machine is equipped with a scraper near the inner wall of the filter screen at the outer edge of the spiral blade. A stirring rod is connected to the lower end of the rotating shaft, and the stirring rod is located in the conical discharge hopper.

⑤ The solvent-based vacuum filtration and drying device is also equipped with a vacuum hole connected to the vacuum device on the cylinder body.

Performance advantages of the fully sealed crystallization, filtration, washing and drying integrated machine for hormone-based pharmaceutical intermediates

From the actual operation and use of the fully sealed crystallization, filtration, washing and drying integrated machine in processing various hormone-based pharmaceutical intermediates, it can be found that the four-in-one multi-functional equipment has many advantages, mainly manifested as:

① Multi-functional in one machine, it can complete various operations such as reaction, extraction, filtration, repeated filtration and washing, and drying within one machine, and directly obtain the finished product.

② It has a large operational flexibility. The operation cycle can be adjusted by regulating the filtration pressure difference, rotational speed, screw extrusion lead, etc., to adapt to changes in process conditions.

③ This machine can form a very thin filter cake on the surface of the filter medium or perform filtration without a filter cake. The filtration rate per unit filtration area is very high, so the equipment is small and compact.

④ Fully enclosed system, with a very good operating environment, is particularly suitable for handling toxic, flammable, explosive and dangerous products, as well as fresh and delicious foods, biological products and medicines that are not allowed to be contaminated.

It can both concentrate and filter. Especially when it is necessary to wash the materials, the materials can be concentrated first and then thoroughly washed in a suspended state. Finally, they can be pressed and filtered. This can reduce the handling of materials, minimize waste, and there is no need for slurry during washing. The quality of the processed products is very high.

It can be used for three operations: reaction, filtration and drying, enabling the functions of the three unit devices to be accomplished on this single device. As a result, the equipment cost, floor space, labor intensity and energy consumption are all significantly reduced.

⑦ This machine has low power consumption. The moisture content of the filter cake it extrudes is generally lower than that of the three-in-one plate type, and it is also convenient to operate.

Wuxi Sunray has designed a new type of fully enclosed crystallization, filtration, washing and drying integrated machine based on the traditional organic solvent extraction process for hormone-based pharmaceutical intermediates. This machine can greatly improve the working environment and increase the recovery rate of solvents. The multi-functional equipment for medical-grade filtration, washing and drying simplifies the process flow and solves the pollution problem caused by multiple turnovers due to the multiple processes of spin-drying, washing and drying being completed on different equipment in the traditional process. This device is not only suitable for the drying of solvent-based crystalline substances, but also for the production of fine particle crystalline substances of active pharmaceutical ingredients. It has extremely strong practical value and is worthy of promotion and application.